Almost every adult male knows the name of the most popular drug for today to increase potency in men – Super Leeforce. Once, when the pharmaceutical company Pfizer just released Viagra on the market, the medicine made a real breakthrough in treating the problems of potency in men. The active ingredient in Viagra is the substance sildenafil (sildenafilum), it is its inclusion in the composition of the drug that allows you to increase the potency.
The mechanism of exposure can be briefly described thus: during sexual stimulation, a man produces a large amount of cyclic guanosine monophosphate (cGMP), the effect of which on the body is to relax the smooth muscles of the penis. This in turn leads to an increase in their blood supply, which contributes to the appearance of an erection. In the body of a man there is a substance of phosphodiesterase (PDE), which destroys cGMP. Sildenafil inhibits PDE, which increases the amount of cyclic guanosine monophosphate and increases the erection. Also an important point, separately voiced by the manufacturer, are the conditions under which the Super Leeforce drug works. The effect develops in men only in the presence of sexual stimulation, that is, the erection does not arise by itself.
Similar effects and analogues of the drug – its generics. When taking the drug with fatty foods, the pharmacokinetic index of Cmax decreases by at least 20% (sometimes up to 40%), it takes from 1.5 to 3 hours to achieve it. Metabolization of sildenafil occurs in the liver under the influence of microsomal isozymes of the cytochrome system. The half-life of sildenafil in pure form and N-desmethyl metabolite, which is its main metabolite, is from 3 to 5 hours. The drug is excreted as inactive metabolic products. About 80% is eliminated with the contents of the intestine, about 15% is eliminated by the kidneys.