Faced with the problem of easing or lack of erection, many men are beginning to what is levitra be interested in drugs to increase potency. Medicines for sexual impotence are today considered to be the simplest, most effective and fastest way to restore sexual function, so they are in great demand and popular. However, not every drug offered in the pharmacy is able to eliminate erectile dysfunction and give a high result. In view of this, men face a difficult choice and do not know which means to give preference. According to many experts, one of the best pharmacological products for dealing with impaired potency is Levitra.
Let’s try to figure out what Levitra is, how it works and in what cases it is appointed.
Levitra is a modern preparation of synthetic origin, which is based on vardenafil.
It is made in the form of round tablets containing 5, 10 or 20 mg of the active substance. It is produced in special blisters. How real is Levitra’s medication, what is vardenafil and what should be expected after its application?
The high effectiveness of the drug is what is levitra proved by studies and long-term clinical practice. Therefore, Levitra is rightfully in the lead among drugs for the treatment of erectile dysfunction. An excellent effect is observed in 90% of patients who use these tablets. Levitra helps with sexual impotence, caused by physiological and psychological causes, as well as factors of a different nature. The drug is successfully used in the treatment of erectile dysfunction, which arose against the background of the development of diabetes.
The main component of vardenafil refers to PDE-5 inhibitors, that is, blocks the activity of a specific enzyme.
Due to the action of Levitra’s main substance, an increase in the level of cGMP occurs, which leads to a relaxation of the smooth muscles of large vessels passing through the genital organ. The influx of blood to the penis increases and against this background, there is a natural powerful erection.
It is worth saying that levitra oral jelly, like other similar means, does not affect the sexual system of men in the absence of sexual desire – sexual stimulation. This is due to the fact that the pills are not artificial stimulants and only affect the natural physiological processes.
- Quick action. The effect of taking Levitra can be observed after 40 minutes. Men have a good persistent erection, there is an opportunity to make a full and successful sexual intercourse.
- Long-lasting result. After applying the drug, the erection persists for 8-12 hours. During this time, men can repeatedly enter into sexual contact. The only condition is the desire for intimacy (stimulation).
- Good tolerability. On the part of the body’s systems, Levitra causes only mild side effects, which do not cause much anxiety. There are reactions to the drug, such as mild headache, dizziness, redness of the face. Dyspepsia, nausea, and temporary visual impairment are less common.
- The minimum of contraindications. The drug should not be taken by minors, as well as adult representatives of the stronger sex with increased sensitivity to the what is levitra components of Levitra, with severe heart, liver or kidney disease. Contraindication is the simultaneous use of tablets for potency with drugs that contain nitrates.
- High effect. The medicine helps to restore sexual power even with the development of complete impotence and successfully copes with erectile disorders of varying severity.
The only drawback of these powerful pills is their high and not affordable price. On our site, you can buy an analog of the original tablets – generic Levitra , which has all the described positive properties, but is more affordable.
Mode of Application Levitra
Finding out what Levitra is, you need to get acquainted with the recommendations regarding its reception. Indication for the use of the tool is the inability of men to maintain the erection necessary for penetration and sexual intercourse. Tablets should not be taken more than once in 24 hours. The maximum single dose is 20 mg. The norm may decrease to 10 or 5 mg. Tablets are used 30-40 minutes before the start of sex, swallowing whole and washing down with water. Time of food intake does not matter. However, it is not advisable to drink alcohol and fatty foods that can slow down the effect of vardenafil.
Levitra is an effective, safe and safe medicine designed to improve potency.
Individual sensitivity to Levitra components; simultaneous intake of nitrates or any NO donors; simultaneous administration of vardenafil with HIV protease inhibitors (indinavir and ritonavir).
The drug for women is not intended.
Levitra should be administered with caution to men with anatomical deformation of the penis; with diseases that promote the development of priapism.
Interaction with other drugs and alcohol:
The clearance of vardenafil may decrease under the influence of inhibitors of CYP (enzymes of the cytochrome system).
Cimetidine (400 mg twice daily), a nonspecific inhibitor of cytochrome P 450, does not affect AUC and Cmax vardenafil.
Erythromycin (500 mg 3 times a day), an inhibitor of CYP3A 5, results in a 4-fold increase in AUC vardenafil and a 3-fold increase what is levitra in Cmax vardenafil.
Ketoconazole (200 mg) leads to a 10-fold increase in AUC vardenafil and a 4-fold increase in Cmax vardenafil.
The combination of vardenafil (10 mg) with the HIV protease inhibitor indinavir (800 mg 3 times a day) causes a 16-fold increase in AUC vardenafil and a 7-fold increase in Cmax vardenafil.
Ritonavir (600 mg twice daily) leads to a 13-fold increase in Cmaxvardenafil and a 49-fold increase in AUC0-24 vardenafil with simultaneous use of vardenafil (5 mg).
Combination with potent inhibitors of the enzymes of the cytochrome P-450 3A 4 system (CYP3A4) (ketoconazole, itraconazole, indinavir, ritonavir) causes a significant increase in vardenafil plasma levels. When Levitra is combined with erythromycin or clarithromycin, ketoconazole or itraconazole, a dose of 5 mg should not be exceeded. Do not take Vardenafil with doses of ketoconazole and itraconazole above 200 mg. The combination of the drug with indinavir and ritonavir is contraindicated. Nitrates, nitric oxide donors:
- There was no increase in the hypotensive effect of nitroglycerin, applied sublingually (0.4 mg), with the use of vardenafil (10 mg) at different times (1-24 hours) prior to the use of a dose of nitroglycerin. The hypotensive effect of nitrates applied sublingually (0.4 mg) at 1 and 4 hours after taking vardenafil was enhanced with 20 mg of vardenafil. These effects were not observed with the administration of vardenafil 20 mg per day prior to the use of nitroglycerin. There is no information on the potential hypotensive effects of vardenafil when what is levitra combined with nitrates, and their simultaneous use is contraindicated. Alpha-blockers: The results of the studies do not indicate a significant effect of acetylsalicylic acid, ACE inhibitors, beta-blockers, weak inhibitors of CYP3A 4, diuretics and drugs for diabetes (sulfonylureas and metformin) on the pharmacokinetics of vardenafil. Other medicines: vardenafil (20 mg) when combined with glibenclamide (3.5 mg) does not affect the relative bioavailability of glibenclamide. There is no evidence that the pharmacokinetics of vardenafil change under the influence of glibenclamide.
- Pharmacokinetic and pharmacodynamic effects were not observed with simultaneous use of warfarin (25 mg) and vardenafil (20 mg). The pharmacokinetics of vardenafil changed with combination with warfarin. Pharmacokinetic interaction with simultaneous use of vardenafil (20 mg) with nifedipine (30 mg or 60 mg) was not observed. The combination of vardenafil and nifedipine did not lead to pharmacodynamic interaction.
Composition and properties:
One tablet contains 5 mg, 10 mg or 20 mg of vardenafil (5.926 mg, 11.852 mg or 23.705 mg of vardenafil monohydrochloride, three hydrates sotstvensvenno);
Excipients: crospovidone, magnesium what is levitra stearate, microcrystalline cellulose, silicon dioxide anhydrous, macrogol 400, hypromelose, titanium dioxide (E 171), iron oxide yellow (E 172), iron oxide red (E 172).